Description
Recombinant full-length human BIRC3 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Scientific Background: BIRC3 or baculoviral IAP repeat containing 3 is a member of the IAP family of proteins. BIRC3 inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and thereby interfering with activation of ICE-like proteases. BIRC3 inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. BIRC3 is a potential oncogene which is overexpressed in multiple lung cancers with or without higher copy numbers (1). BIRC3 is a key regulator of NOD innate immunity signaling (2)